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Lehninger principles of biochemistry / David L. Nelson, Michael M. Cox

Main Author Nelson, David L., 1942- Coauthor Cox, Michael M. Secondary Author Lehninger, Albert L. Country Estados Unidos. Edition 5th ed Publication New York : W. H. Freeman, cop. 2008 Description 1295 p., pag. var. : il., color ; 29 cm ISBN 0-7167-7108-X
CDU 577.1
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Monografia Biblioteca Prof. Joaquim Pinto Machado
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Monografia Biblioteca Prof. Joaquim Pinto Machado
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Licenciatura em Química Bioquímica 1º semestre

Licenciatura em Biologia Aplicada Bioenergética e Metabolismo 1º semestre

Licenciatura em Bioquímica Metabolismo e regulação II 2º semestre

Licenciatura em Optometria e Ciências da Visão Bioquímica 2º semestre

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Enhanced descriptions from Syndetics:

In the Fifth Edition, authors Dave Nelson and Mike Cox combine the best of the laboratory and best of the classroom, introducing exciting new developments while communicating basic principles through a variety of new learning tools--from new in-text worked examples and data analysis problems to the breakthrough eBook, which seamlessly integrates the complete text and its media components.

Table of contents provided by Syndetics

  • 1 The Foundations of Biochemistry
  • 1.1 Cellular Foundations
  • 1.3 Physical Foundations
  • 1.5 Evolutionary Foundations
  • 1.2 Chemical Foundations
  • 1.4 Genetic Foundations
  • 1-2 Louis Pasteur and Optical Activity: In Vino, Veritas
  • 1-3 Entropy: The Advantages of Being Disorganized
  • Updated section on how a new species evolves
  • Increased emphasis on the interdependence of life forms in global cycles of energy
  • I Structure and Catalysis
  • 2 Water
  • 2.1 Weak Interactions in Aqueous Systems
  • 1-1 Molecular Weight, Molecular Mass, and Their Correct Units
  • Now introduces the concepts of proteomes and proteomics
  • 2.2 Ionization of Water, Weak Acids, and Weak Bases
  • 2.3 Buffering against pH Changes in Biological Systems
  • 2-1 Medicine: On Being One's Own Rabbit (Don't Try This at Home!)
  • 2.4 Water as a Reactant
  • 2.5 The Fitness of the Aqueous Environment for Living Organisms
  • New section on ketoacidosis in diabetes
  • 3.1 Amino Acids
  • 3.2 Peptides and Proteins
  • 3.4 The Structure of Proteins: Primary Structure
  • Expanded discussion of blood pH buffering by the bicarbonate system,including a new box describing Haldane's use of himself as a guinea pig in experiments aimed at changing the acidity of blood
  • 3 Amino Acids, Peptides, and Proteins
  • 3.3 Working with Proteins
  • 3-2 Methods: Investigating Proteins with Mass Spectrometry
  • 3-3 Medicine: Consensus Sequences and Sequence Logos
  • Significant revision to bioinformatics
  • 4.1 Overview of Protein Structure
  • 3-1 Methods: Absorption of Light by Molecules: The Lambert-Beer Law
  • More thorough explanation of consensus sequences, including an illustration of common ways to depict consensus sequences
  • 4 The Three-Dimensional Structure of Proteins
  • 4.2 Protein Secondary Structure
  • 4.3 Protein Tertiary and Quaternary Structures
  • 4.4 Protein Denaturation and Folding
  • 4-1 Methods: Knowing the Right Hand from the Left
  • 4-2 Permanent Waving Is Biochemical Engineering
  • 4-3 Medicine: Why Sailors, Explorers, and College Students Should Eat Their Fresh Fruits and Vegetables
  • 4-4 The Protein Data Bank
  • 4-6 Medicine: Death by Misfolding: The Prion Diseases
  • New section, Defects in protein folding may be the molecular basis for a wide range of human genetic disorders, discusses a variety of amyloid diseases
  • 5 Protein Function
  • 5.1 Reversible Binding of a Protein to a Ligand: Oxygen-Binding Proteins
  • 5.2 Complementary Interactions between Proteins and Ligands: The Immune System and Immunoglobulins
  • 5.3 Protein Interactions Modulated by Chemical Energy: Actin, Myosin, and Molecular Motors
  • 5-1 Medicine: Carbon Monoxide: A Stealthy Killer
  • 6 Enzymes
  • 6.1 An Introduction to Enzymes
  • 6.2 How Enzymes Work
  • 6.3 Enzyme Kinetics as an Approach to Understanding Mechanism
  • 6.4 Examples of Enzymatic Reactions
  • 6.5 Regulatory Enzymes
  • 6-1 Transformations of the Michaelis-Menten Equation: The Double-Reciprocal Plot
  • 6-2 Kinetic Tests for Determining Inhibition Mechanisms
  • 6-3 Evidence for Enzyme-Transition State Complementarity
  • More explanatory text added to the mechanisms for the enolase and lysozyme reactions
  • New section on pharmaceuticals developed from an understanding of enzyme mechanism, using penicillin and HIV protease inhibitors as examples
  • 7 Carbohydrates and Glycobiology
  • 7.1 Monosaccharides and Disaccharides
  • 7.2 Polysaccharides
  • 7.3 Glycoconjugates: Proteoglycans, Glycoproteins, and Glycolipids
  • 7.5 Working with Carbohydrates
  • 7-1 Medicine: Blood Glucose Measurements in the Diagnosis and Treatment of Diabetes
  • New medical box, introduces hemoglobin glycation and AGEs and their role in the pathology of advanced diabetes
  • New section on sugar analogs as drugs that target viral neuraminidase
  • Introduction to the new field of glycomics, including methods for determining oligosaccharide structure using MALDI-MS
  • 8 Nucleotides and Nucleic Acids
  • 8.1 Some Basics
  • 8.2 Nucleic Acid Structure
  • 8.3 Nucleic Acid Chemistry
  • 4-5 Methods: Methods for Determining the Three-Dimensional Structure of a Protein
  • New section on circular dichroism
  • 7.4 Carbohydrates as Informational Molecules: The Sugar Code
  • 8.4 Other Functions of Nucleotides
  • 9 DNA-Based Information Technologies
  • 9.1 DNA Cloning: The Basics
  • 9.2 From Genes to Genomes
  • 9.3 From Genomes to Proteomes
  • 9.4 Genome Alterations and New Products of Biotechnology
  • 9-1 Medicine: A Potent Weapon in Forensic Medicine
  • 9-2 Medicine: The Human Genome and Human Gene Therapy
  • New material on the green fluorescent protein
  • Thorough updating of genomics section
  • 10 Lipids
  • 10.1 Storage Lipids
  • 10.2 Structural Lipids in Membranes
  • 10.3 Lipids as Signals, Cofactors, and Pigments
  • 10.4 Working with Lipids
  • 10-1 Sperm Whales: Fatheads of the Deep
  • 10-2 Medicine: Abnormal Accumulations of Membrane Lipids: Some Inherited Human Diseases
  • New medical section on the role of polyunsaturated fatty acids and trans fatty acids in cardiovascular disease
  • New section on lipidomics
  • New descriptions of volatile lipids used as signals by plants, and pigments of bird feathers derived from colored lipids in plant foods
  • 11 Biological Membranes and Transport
  • 11.1 The Composition and Architecture of Membranes
  • 11.2 Membrane Dynamics
  • 11.3 Solute Transport across Membranes
  • 11-1 Methods: Atomic Force Microscopy to Visualize Membrane Proteins
  • 11-2 Medicine: Defective Glucose and Water Transport in Two Forms of Diabetes
  • 11-3 Medicine: A Defective Ion Channel in Cystic Fibrosis
  • Expanded and updated section on lipid rafts and caveolae includes new material on membrane curvature and the proteins that influence it, and introduces amphitropic proteins and annular lipids
  • New information on the structural basis for voltage gating in a K+ channel
  • 12.1 General Features of Signal Transduction
  • 12.2 G Protein-Coupled Receptors and Second Messengers
  • 12.3 Receptor Tyrosine Kinases
  • 12.4 Receptor Guanylyl Cyclases, cGMP, and Protein Kinase G
  • 12.5 Multivalent Scaffold Proteins and Membrane Rafts
  • 12.6 Gated Ion Channels
  • 12.7 Integrins: Bidirectional Cell Adhesion Receptors
  • 12.8 Regulation of Transcription by Steroid Hormones
  • 12.9 Signaling in Microorganisms and Plants
  • 12.10 Sensory Transduction in Vision, Olfaction, and Gustation
  • 12.11 Regulation of the Cell Cycle by Protein Kinases
  • 12.12 Oncogenes, Tumor Suppressor Genes, and Programmed Cell Death
  • 12-1 Methods: Scatchard Analysis Quantifies the Receptor-Ligand Interaction
  • 12-2 Medicine: G Proteins: Binary Switches in Health and Disease
  • 12-3 Methods: FRET: Biochemistry Visualized in a Living Cell
  • 12-5 Medicine: Development of Protein Kinase Inhibitors for Cancer Treatment
  • New Medical section on G protein coupled receptors (GCPRs) discusses the range of diseases for which drugs target GPCRs
  • New box on G proteins, proteins that regulate their GTPase activity, and the medical consequences of defective G protein function
  • Expanded and integrated treatment of local signaling circuits, including AKAPs and signaling complexes that include protein kinase A, adenylyl cyclase, and phosphodiesterase, and localized puffs and waves of Ca2+
  • New medical box on the use of protein kinase inhibitors in cancertherapy
  • II Bioenergetics and Metabolism
  • 13 Bioenergetics and Biochemical Reaction Types
  • Expanded section on bilayer dynamics covers flippases, floppases, scramblases, and bilayer asymmetry
  • 12 Biosignaling
  • 12-4 Medicine: Color Blindness: John Dalton's Experiment from the Grave
  • 13.1 Bioenergetics and Thermodynamics
  • 13.2 Chemical Logic and Common Biochemical Reactions
  • 13.3 Phosphoryl Group Transfers and ATP
  • 13.4 Biological Oxidation-Reduction Reactions
  • 13-1 Firefly Flashes: Glowing Reports of ATP
  • New section, Chemical logic and common biochemical reactions, discusses common biochemical reaction types
  • 14.2 Feeder Pathways for Glycolysis
  • 14.3 Fates of Pyruvate under Anaerobic Conditions: Fermentation
  • 14.4 Gluconeogenesis
  • 14.5 Pentose Phosphate Pathway of Glucose Oxidation
  • 14-1 Medicine: High Rate of Glycolysis in Tumors Suggests Targets for Chemotherapy and Facilitates Diagnosis
  • 14-2 Athletes, Alligators, and Coelacanths: Glycolysis at Limiting Concentrations of Oxygen
  • 14-3 Ethanol Fermentations: Brewing Beer and Producing Biofuels
  • 14-4 Medicine: Why Pythagoras Wouldn't Eat Falafel: Glucose 6-Phosphate Dehydrogenase Deficiency
  • New medical box on glucose uptake deficiency in type 1 diabetes
  • New medical box on how the high rate of glycolysis in cancerous tissue aids cancer diagnosis and treatment
  • 14 Glycolysis, Gluconeogenesis, and the Pentose Phosphate Pathway
  • 14.1 Glycolysis
  • 15 Principles of Metabolic Regulation
  • 15.1 Regulation of Metabolic Pathways
  • 15.2 Analysis of Metabolic Control
  • 15.3 Coordinated Regulation of Glycolysis and Gluconeogenesis
  • 15.4 The Metabolism of Glycogen in Animals
  • 15.5 Coordinated Regulation of Glycogen Synthesis and Breakdown
  • 15-1 Methods: Metabolic Control Analysis: Quantitative Aspects
  • 15-2 Isozymes: Different Proteins That Catalyze the Same Reaction
  • 15-3 Medicine: Genetic Mutations That Lead to Rare Forms of Diabetes
  • 15-4 Carl and Gerty Cori: Pioneers in Glycogen Metabolism and Disease
  • New section on emerging role of ribulose 5-phosphate as central regulator of glycolysis and gluconeogenesis
  • Expanded discussion of phosphoprotein phosphatases in metabolic regulation
  • Expanded coverage of the role of transcriptional regulators in metabolic regulation
  • New medical box on mutations that lead to rare forms of diabetes regulation (MODY)
  • 16 The Citric Acid Cycle
  • 16.1 Production of Acetyl-CoA (Activated Acetate)
  • 16.2 Reactions of the Citric Acid Cycle
  • 16.3 Regulation of the Citric Acid Cycle
  • 16.4 The Glyoxylate Cycle
  • 16-1 Moonlighting Enzymes: Proteins with More Than One Job
  • 16-2 Synthases and Synthetases; Ligases and Lyases; Kinases,Phosphatases, and Phosphorylases: Yes, the Names Are Confusing!
  • 16-3 Citrate: A Symmetric Molecule That Reacts Asymmetrically
  • 16-4 Citrate Synthase, Soda Pop, and the World Food Supply
  • New box on effect of diabetes on the citric acid cycle and ketone body formation
  • Expanded discussion of substrate channeling
  • New section on mutations in citric acid cycle that lead to cancer
  • New box on moonlighting enzymes
  • 17 Fatty Acid Catabolism
  • 17.1 Digestion, Mobilization, and Transport of Fats
  • 17.3 Ketone Bodies
  • 17-1 Fat Bears Carry Out b Oxidation in Their Sleep
  • New section on the role of transcription factors (PPARs) in regulation of lipid catabolism
  • 18 Amino Acid Oxidation and the Production of Urea
  • 18.1 Metabolic Fates of Amino Groups
  • 18.2 Nitrogen Excretion and the Urea Cycle
  • 18.3 Pathways of Amino Acid Degradation
  • 18-1 Medicine: Assays for Tissue Damage
  • 18-2 Medicine: Scientific Sleuths Solve a Murder Mystery
  • New section on pernicious anemia and associated problems in strict vegetarians.
  • 19 Oxidative Phosphorylation and Photophosphorylation Oxidative Phosphorylation
  • 19.1 Electron-Transfer Reactions in Mitochondria
  • 17.2 Oxidation of Fatty Acids
  • 17-2 Coenzyme B12: A Radical Solution to a Perplexing Problem
  • 19.2 ATP Synthesis
  • 19.3 Regulation of Oxidative Phosphorylation
  • 19.4 Mitochondria in Thermogenesis, Steroid Synthesis, and Apoptosis
  • 19.5 Mitochondrial Genes: Their Origin and the Effects of Mutations Photosynthesis: Harvesting Light Energy
  • 19.6 General Features of Photophosphorylation
  • 19.7 Light Absorption
  • 19.8 The Central Photochemical Event: Light-Driven Electron Flow
  • 19.9 ATP Synthesis by Photophosphorylation
  • 19.10 The Evolution of Oxygenic Photosynthesis
  • 19-1 Hot, Stinking Plants and Alternative Respiratory Pathways
  • Updated discussion of the structure of the electron transfer complexes of mitochondria and chloroplasts, and of the Fo complex
  • Updated description of the water-splitting complex's structure in chloroplasts
  • Expanded description of mitochondrial diseases and mitochondrial role in diabetes
  • 20 Carbohydrate Biosynthesis in Plants and Bacteria
  • 20.1 Photosynthetic Carbohydrate Synthesis
  • 20.2 Photorespiration and the C4 and CAM Pathways
  • 20.3 Biosynthesis of Starch and Sucrose
  • 20.4 Synthesis of Cell Wall Polysaccharides: Plant Cellulose and Bacterial Peptidoglycan
  • 20.5 Integration of Carbohydrate Metabolism in the Plant Cell
  • 21 Lipid Biosynthesis
  • 21.1 Biosynthesis of Fatty Acids and Eicosanoids
  • 21.2 Biosynthesis of Triacylglycerols
  • 21.3 Biosynthesis of Membrane Phospholipids
  • 21.4 Biosynthesis of Cholesterol, Steroids, and Isoprenoids
  • 21-1 Mixed-Function Oxidases, Oxygenases, and Cytochrome P-450
  • Revised and updated section on fatty acid synthase includes new structural information on FAS I
  • Updated information on cyclooxygenase inhibitors (pain relievers Vioxx, Celebrex, Bextra)
  • New information on HMG-CoA reductase and new medical box on statins
  • 22 Biosynthesis of Amino Acids, Nucleotides, and Related Molecules
  • 22.1 Overview of Nitrogen Metabolism
  • 22.2 Biosynthesis of Amino Acids
  • 22.3 Molecules Derived from Amino Acids
  • 22.4 Biosynthesis and Degradation of Nucleotides
  • 22-1 Unusual lifestyles of the obscure but abundant
  • 22-2 Medicine: On Kings and Vampires
  • Updated coverage of nitrogen cycle section includes a new box on anammox bacteria
  • New information on therapy for acute lymphoblastic leukemia
  • New information on folic acid deficiency
  • 23 Hormonal Regulation and Integration of Mammalian Metabolism
  • 23.1 Hormones: Diverse Structures for Diverse Functions
  • 23.2 Tissue-Specific Metabolism: The Division of Labor
  • 23.3 Hormonal Regulation of Fuel Metabolism
  • 23.4 Obesity and the Regulation of Body Mass
  • 23-1 Medicine: How Is a Hormone Discovered? The Arduous Path to Purified Insulin
  • Expanded coverage and updating of the biochemical connections between obesity, metabolic syndrome, and type 2 diabetes
  • 22-3 Medicine: Curing African Sleeping Sickness with a Biochemical Trojan Horse
  • 23.5 Obesity, the Metabolic Syndrome, and Type 2 Diabetes
  • Updated discussion of the integration of fuel metabolism in fed and starved states in diabetes
  • III Information Pathways
  • 24 Genes and Chromosomes
  • 24.1 Chromosomal Elements
  • 24.2 DNA Supercoiling
  • 24-1 Medicine: Curing Disease by Inhibiting Topoisomerases
  • 24-2 Medicine: Epigenetics, Nucleosome Structure, and Histone Variants
  • New material on histone modification, histone variants, and nucleosome deposition
  • New medical box on the use of topoisomerase inhibitors in the treatment of bacterial infections and cancer, includes material on ciprofloxacin (the antibiotic effective for anthrax)
  • 25 DNA Metabolism
  • 25.1 DNA Replication
  • 25.2 DNA Repair
  • 25.3 DNA Recombination
  • 25-1 Medicine: DNA Repair and Cancer
  • 24.3 The Structure of Chromosomes
  • New box on the role of histone modification and nucleosome deposition in the transmission of epigenetic information in heredity
  • New information on the initiation of replication and the dynamics at the replication fork, introducing AAA+ ATPases and their functions in replication and other aspects of DNA metabolism
  • 26 RNA Metabolism
  • 26.1 DNA-Dependent Synthesis of RNA
  • 26.2 RNA Processing
  • 26.3 RNA-Dependent Synthesis of RNA and DNA
  • 26-1 Methods: RNA Polymerase Leaves Its Footprint on a Promoter
  • 26-2 Fighting AIDS with Inhibitors of HIV Reverse Transcriptase
  • 26-3 Methods: The SELEX Method for Generating RNA Polymers with New Functions
  • 26-4 An Expanding RNA Universe Filled with TUF RNAs
  • New section on the expanding roles of RNA in cells
  • 27 Protein Metabolism
  • 27.1 The Genetic Code
  • 27.2 Protein Synthesis
  • 27.3 Protein Targeting and Degradation
  • 27-1 Exceptions That Prove the Rule: Natural Variations in the Genetic Code
  • 27-2 From an RNA World to a Protein World
  • 27-3 Natural and Unnatural Expansion of the Genetic Code
  • 27-4 Induced Variation in the Genetic Code: Nonsense Suppression
  • Expanded section on protein synthesis coupled to the advances in ribosome structure
  • New information on the roles of RNA in protein biosynthesis
  • 28 Regulation of Gene Expression
  • 28.2 Regulation of Gene Expression in Bacteria
  • 28-1 Of Fins, Wings, Beaks, and Things
  • New information about roles of RNA in gene regulation
  • New box on the connections between evolution and development
  • Appendix A Common Abbreviations in the Biochemical Research Literature
  • Appendix B Abbreviated Solutions to Problems
  • Glossary
  • Credits
  • Index
  • 28.3 Regulation of Gene Expression in Eukaryotes
  • 28.1 Principles of Gene Regulation

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