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Development of sustainable bioprocesses : modeling and assessment / Elmar Heinzle, Arno P. Biwer, Charles L. Cooney

Main Author Heinzle, Elmar Coauthor Biwer, Arno P.
Cooney, Charles L.
Country Reino Unido. Publication Chichester : John Wiley, cop. 2006 Description XXI, 294 p. : il., gráficos ; 25 cm + 1 disco óptico (CD-ROM) ISBN 0-470-01559-4
978-0-470-01559-9
CDU 66.098
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Holdings
Item type Current location Call number Status Date due Barcode Item holds Course reserves
Monografia Biblioteca de Engenharia Biológica
BEB 66.098 - H Indisponível | Not available 371591
Produtos Computador Biblioteca de Engenharia Biológica
BEB 66.098 - H Indisponível | Not available 371592

Mestrado Integrado em Engenharia Biológica Projeto em Engenharia de Processo 2º semestre

Total holds: 0

Enhanced descriptions from Syndetics:

Bioprocess technology involves the combination of living matter (whole organism or enzymes ) with nutrients under laboratory conditions to make a desired product within the pharmaceutical, food, cosmetics, biotechnology, fine chemicals and bulk chemicals sectors. Industry is under increasing pressure to develop new processes that are both environmentally friendly and cost-effective, and this can be achieved by taking a fresh look at process development; - namely by combining modern process modeling techniques with sustainability assessment methods.

Development of Sustainable Bioprocesses: Modeling and Assessment describes methodologies and supporting case studies for the evolution and implementation of sustainable bioprocesses. Practical and industry-focused, the book begins with an introduction to the bioprocess industries and development procedures. Bioprocesses and bioproducts are then introduced, together with a description of the unit operations involved. Modeling procedures, a key feature of the book, are covered in chapter 3 prior to an overview of the key sustainability assessment methods in use (environmental, economic and societal). The second part of the book is devoted to case studies, which cover the development of bioprocesses in the pharmaceutical, food, fine chemicals, cosmetics and bulk chemicals industries. Some selected case studies include: citric acid, biopolymers, antibiotics, biopharmaceuticals.

Supplementary material provides hands-on materials so that the techniques can be put into practice. These materials include a demo version of SuperPro Designer software (used in process engineering) and models of all featured case studies, excel sheets of assessment methods, Monte Carlo simulations and exercises.

Previously available on CD-ROM, the supplementary material can now be accessed via http://booksupport.wiley.com by entering the author name, book title or isbn and clicking on the desired entry. This will then give a listing of all the content available for download. Please read any text files before downloading material.

Table of contents provided by Syndetics

  • Preface (p. xiii)
  • Acknowledgments (p. xvii)
  • List of Contributors (p. xix)
  • Part I Theoretical Introduction
  • 1 Introduction (p. 3)
  • 1.1 Bioprocesses (p. 3)
  • 1.1.1 History of Biotechnology and Today's Situation (p. 3)
  • 1.1.2 Future Perspectives (p. 6)
  • 1.2 Modeling and Assessment in Process Development (p. 7)
  • 2 Development of Bioprocesses (p. 11)
  • 2.1 Types of Bioprocess and Bioproduct (p. 11)
  • 2.1.1 Biocatalysts and Process Types (p. 11)
  • 2.1.2 Raw Materials (p. 17)
  • 2.1.3 Bioproducts (p. 20)
  • 2.2 Bioreaction Stoichiometry, Thermodynamics, and Kinetics (p. 23)
  • 2.2.1 Stoichiometry (p. 23)
  • 2.2.2 Thermodynamics (p. 28)
  • 2.2.3 Kinetics (p. 29)
  • 2.3 Elements of Bioprocesses (Unit Operations and Unit Procedures) (p. 32)
  • 2.3.1 Upstream Processing (p. 33)
  • 2.3.2 Bioreactor (p. 36)
  • 2.3.3 Downstream Processing (p. 40)
  • 2.3.4 Waste Treatment, Reduction and Recycling (p. 50)
  • 2.4 The Development Process (p. 52)
  • 2.4.1 Introduction (p. 52)
  • 2.4.2 Development Steps and Participants (p. 53)
  • 3 Modeling and Simulation of Bioprocesses (p. 61)
  • 3.1 Problem Structuring, Process Analysis, and Process Scheme (p. 62)
  • 3.1.1 Model Boundaries and General Structure (p. 62)
  • 3.1.2 Modeling Steps (p. 63)
  • 3.2 Implementation and Simulation (p. 66)
  • 3.2.1 Spreadsheet Model (p. 66)
  • 3.2.2 Modeling using a Process Simulator (p. 66)
  • 3.3 Uncertainty Analysis (p. 71)
  • 3.3.1 Scenario Analysis (p. 72)
  • 3.3.2 Sensitivity Analysis (p. 73)
  • 3.3.3 Monte Carlo Simulation (p. 75)
  • 4 Sustainability Assessment (p. 81)
  • 4.1 Sustainability (p. 81)
  • 4.2 Economic Assessment (p. 82)
  • 4.2.1 Capital-Cost Estimation (p. 83)
  • 4.2.2 Operating-Cost Estimation (p. 88)
  • 4.2.3 Profitability Assessment (p. 94)
  • 4.3 Environmental Assessment (p. 95)
  • 4.3.1 Introduction (p. 95)
  • 4.3.2 Structure of the Method (p. 96)
  • 4.3.3 Impact Categories and Groups (p. 99)
  • 4.3.4 Calculation of Environmental Factors (p. 103)
  • 4.3.5 Calculation of Indices (p. 105)
  • 4.3.6 Example Cleavage of Penicillin G (p. 105)
  • 4.4 Assessing Social Aspects (p. 107)
  • 4.4.1 Introduction (p. 107)
  • 4.4.2 Indicators for Social Assessment (p. 108)
  • 4.5 Interactions between the Different Sustainability Dimensions (p. 112)
  • Part II Bioprocess Case Studies
  • Introduction to Case Studies (p. 121)
  • 5 Citric Acid - Alternative Process using Starch (p. 125)
  • 5.1 Introduction (p. 125)
  • 5.2 Fermentation Model (p. 125)
  • 5.3 Process Model (p. 128)
  • 5.4 Inventory Analysis (p. 130)
  • 5.5 Environmental Assessment (p. 132)
  • 5.6 Economic Assessment (p. 134)
  • 5.7 Conclusions (p. 135)
  • 6 Pyruvic Acid - Fermentation with Alternative Downstream Processes (p. 137)
  • 6.1 Introduction (p. 137)
  • 6.2 Fermentation Model (p. 137)
  • 6.3 Process Model (p. 138)
  • 6.3.1 Bioreaction and Upstream (p. 138)
  • 6.3.2 Downstream Processing (p. 141)
  • 6.4 Inventory Analysis (p. 142)
  • 6.5 Environmental Assessment (p. 144)
  • 6.6 Economic Assessment (p. 145)
  • 6.7 Conclusions (p. 145)
  • 7 L-Lysine - Coupling of Bioreaction and Process Model (p. 155)
  • 7.1 Introduction (p. 155)
  • 7.2 Basic Strategy (p. 156)
  • 7.3 Bioreaction Model (p. 156)
  • 7.4 Process Model (p. 159)
  • 7.5 Coupling of Bioreaction and Process Model (p. 162)
  • 7.5.1 Assumptions (p. 163)
  • 7.6 Results and Discussion (p. 164)
  • 8 Riboflavin - Vitamin B[subscript 2] (p. 169)
  • 8.1 Introduction (p. 169)
  • 8.2 Biosynthesis and Fermentation (p. 170)
  • 8.3 Production Process and Process Model (p. 171)
  • 8.3.1 Upstream Processing (p. 172)
  • 8.3.2 Fermentation (p. 174)
  • 8.3.3 Downstream Processing (p. 174)
  • 8.4 Inventory Analysis (p. 174)
  • 8.5 Ecological Assessment (p. 175)
  • 8.6 Economic Assessment (p. 176)
  • 8.7 Discussion and Concluding Remarks (p. 177)
  • 9 [Alpha]Cyclodextrin (p. 181)
  • 9.1 Introduction (p. 181)
  • 9.2 Reaction Model (p. 182)
  • 9.3 Process Model (p. 182)
  • 9.3.1 Solvent Process (p. 182)
  • 9.3.2 Non-solvent Process (p. 184)
  • 9.4 Inventory Analysis (p. 185)
  • 9.5 Environmental Assessment (p. 186)
  • 9.6 Economic Assessment (p. 186)
  • 9.7 Conclusions (p. 189)
  • 10 Penicillin V (p. 193)
  • 10.1 Introduction (p. 193)
  • 10.2 Modeling Base Case (p. 193)
  • 10.2.1 Fermentation Model (p. 193)
  • 10.2.2 Process Model (p. 194)
  • 10.3 Inventory Analysis (p. 196)
  • 10.4 Environmental Assessment (p. 197)
  • 10.5 Economic Assessment (p. 197)
  • 10.6 Monte Carlo Simulations (p. 198)
  • 10.6.1 Objective Functions, Variables, and Probability Distributions (p. 198)
  • 10.6.2 Results (p. 201)
  • 10.7 Conclusions (p. 206)
  • 11 Recombinant Human Serum Albumin (p. 211)
  • 11.1 Introduction (p. 211)
  • 11.2 Bioreaction Model (p. 212)
  • 11.2.1 Stoichiometry (p. 212)
  • 11.2.2 Multi-stage Fermentation and Feeding Plan (p. 213)
  • 11.2.3 Total Broth Volume in Production Scale and Raw Material Consumption (p. 214)
  • 11.3 Process Model (p. 215)
  • 11.3.1 Bioreaction (p. 215)
  • 11.3.2 Downstream Processing (p. 215)
  • 11.4 Economic Assessment (p. 218)
  • 11.5 Ecological Assessment (p. 219)
  • 11.6 Conclusions (p. 221)
  • 12 Recombinant Human Insulin (p. 225)
  • 12.1 Introduction (p. 225)
  • 12.1.1 Two-chain Method (p. 226)
  • 12.1.2 Proinsulin Method (p. 226)
  • 12.2 Market Analysis and Design Basis (p. 226)
  • 12.2.1 Process Description (p. 227)
  • 12.2.2 Inventory Analysis and Environmental Assessment (p. 233)
  • 12.2.3 Production Scheduling (p. 234)
  • 12.3 Economic Assessment (p. 235)
  • 12.4 Throughput-Increase Options (p. 237)
  • 12.5 Conclusions (p. 238)
  • 13 Monoclonal Antibodies (p. 241)
  • 13.1 Introduction (p. 241)
  • 13.2 Process Model (p. 241)
  • 13.3 Inventory Analysis (p. 243)
  • 13.4 Economic Assessment (p. 245)
  • 13.5 Environmental Assessment (p. 246)
  • 13.6 Uncertainty Analysis (p. 247)
  • 13.6.1 Scenarios (p. 247)
  • 13.6.2 Sensitivity Analysis (p. 248)
  • 13.6.3 Monte Carlo Simulations (p. 249)
  • 13.7 Conclusions (p. 255)
  • 14 [Alpha]-1-Antitrypsin from Transgenic Plant Cell Suspension Cultures (p. 261)
  • 14.1 Introduction (p. 261)
  • 14.2 Process Description (p. 263)
  • 14.3 Model Description (p. 263)
  • 14.4 Discussion (p. 265)
  • 14.5 Conclusions (p. 268)
  • 15 Plasmid DNA (p. 271)
  • 15.1 Introduction (p. 271)
  • 15.1.1 General (p. 271)
  • 15.1.2 Case Introduction (p. 272)
  • 15.1.3 Process Description (p. 272)
  • 15.2 Model Description (p. 275)
  • 15.2.1 Bioreaction Section (p. 275)
  • 15.2.2 Downstream Sections (p. 276)
  • 15.3 Inventory Analysis (p. 277)
  • 15.4 Economic Assessment (p. 278)
  • 15.5 Environmental Assessment (p. 281)
  • 15.6 Discussion (p. 282)
  • 15.7 Conclusions (p. 283)
  • Index (p. 287)

Author notes provided by Syndetics

Professor Elmar Heinzle , Universität des Saarlandes, Germany

Dr. Charles Cooney , MIT, USA

Both internationally-recognised experts in biochemical engineering and modeling

Dr Arno Biwer , MIT/ Universität des Saarlandes, Germany

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