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Enzymes : a practical introduction to structure, mechanism, and data analysis / Robert A. Copeland

Main Author Copeland, Robert Allen Country Estados Unidos. Publication New York : VCH, cop. 1996 Description XV, 306 p. : il. ; 25 cm ISBN 1-56081-903-0 CDU 577.15
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Item type Current location Call number Status Date due Barcode Item holds Course reserves
Monografia Biblioteca Geral da Universidade do Minho
BGUM 577.15 - C Available 205733
Monografia Biblioteca da UMinho no Campus de Azurém
BPG 577.15 - C Available 210545
Monografia Biblioteca Geral da Universidade do Minho
BGUM 577.15 - C Available 240505

Licenciatura em Bioquímica Enzimologia 1º semestre

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Enhanced descriptions from Syndetics:

Supplemented with appendices providing contact information for suppliers of reagents and equipment for enzyme studies, as well as a survey of useful Internet sites and computer software for enzymatic data analysis, Enzymes, Second Edition is the ultimate practical guide for scientists and students in biochemical, pharmaceutical, biotechnical, medicinal, and agricultural/food-related research.

Table of contents provided by Syndetics

  • A Brief History of Enzymology
  • Chemical Bonds and Reactions in Biochemistry
  • Structural Components of Enzymes
  • Protein-Ligand Binding Equilibria
  • Kinetics of Single-Substrate Enzyme Reactions
  • Chemical Mechanisms in Enzyme Catalysis
  • Experimental Measures of Enzyme Activity
  • Reversible Inhibitors
  • Tight Binding Inhibitors
  • Time-Dependent Inhibition
  • Enzyme Reactions with Multiple Substrates
  • Cooperativity in Enzyme Catalysis
  • Appendices
  • Index

Reviews provided by Syndetics


Copeland's new edition (1st ed., 1996) is a welcome volume for any reader concerned with this important class of biological macromolecules. The book is interesting, informative, and very readable. Though the focus is on enzymes, there is a great deal of information on protein structure, in general, and on receptor-ligand binding. Theoretical discussions of energetics and kinetics are well balanced with practical considerations such as sources of errors and factors affecting the measurement of reaction velocities. Clear examples that bring home important points are sprinkled throughout, and each chapter is well referenced. The book begins with reviews of fundamental concepts of chemistry and the nature of proteins before progressing to a fine kinetic discussion that includes all the appropriate cautions for doing kinetic experiments well and interpreting their results correctly. The last chapters take the work to a level of sophistication that is often omitted, analyzing more complex modes of inhibition and introducing structure-activity relationship studies. A valuable acquisition for academic libraries. Upper-division undergraduates and above. J. A. Kelly; University of Connecticut

Author notes provided by Syndetics

Robert Copeland is Director of Chemical Enzymology at the DuPont Pharmaceuticals Company and Adjunct Professor of Biochemistry and Biophysics at the University of Pennsylvania School of Medicine

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